Koh H-J, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, et al. Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Molecular and cellular biology. 2006;26(22):8217–8227.
Publications
2006
2005
Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. American Journal of Physiology-Endocrinology and Metabolism. 2005;289(2):E337–E346.
Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng Y-H, Roberson RS, Ricordi C, O\textquoterightConnell PJ, Gonzalez FJ, et al. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell. 2005;122(3):337–349.
Bates SH, Kulkarni RN, Seifert M, Myers MG Jr. Roles for leptin receptor/STAT3-dependent and-independent signals in the regulation of glucose homeostasis. Cell metabolism. 2005;1(3):169–178.
Kulkarni RN. New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass. Reviews in Endocrine and Metabolic Disorders. 2005;6(3):199–210.
2004
Goren J, Kulkarni RN, Kahn R. Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. Endocrinology. 2004;145(7):3307–3323.
Kulkarni RN, Roper MG, Dahlgren G, Shih DQ, Kauri LM, Peters JL, Stoffel M, Kennedy RT. Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco (endo) plasmic reticulum Ca2+-ATPase (SERCA)-2b and-3. Diabetes. 2004;53(6):1517–1525.
Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn R. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. The Journal of clinical investigation. 2004;114(6):828–836.
Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, Stoffel M, Kahn R, Polonsky KS. Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. American journal of physiology-endocrinology and metabolism. 2004;286(1):E41–E49.
Kulkarni RN. The islet beta-cell. Int J Biochem Cell Biol. 2004;36:365–371.