Aspinwall CA, Qian W-J, Roper MG, Kulkarni RN, Kahn R, Kennedy RT. Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta-cells. Journal of Biological Chemistry. 2000;275(29):22331–22338.
Publications
2000
Kahn R, Brüning JС, Michael D, Kulkarni RN. Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus. Journal of Pediatric Endocrinology and Metabolism. 2000;13(Supplement):1377–1384.
1999
Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn R. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell. 1999;96(3):329–339.
Kulkarni RN, Winnay JN, Daniels M, Brüning JC, Flier SN, Hanahan D, Kahn R. Altered function of insulin receptor substrate-1–deficient mouse islets and cultured beta-cell lines. The Journal of clinical investigation. 1999;104(12):R69–R75.