Zhang Z, Liew CW, Handy DE, Zhang Y, Leopold JA, Hu J, Guo L, Kulkarni RN, Loscalzo J, Stanton RC. High glucose inhibits glucose-6-phosphate dehydrogenase leading to increased oxidative stress and beta cell apoptosis. The FASEB Journal. 2010;24(5):1497–1505.
Publications by Year: 2010
2010
Georgia S, Hinault C, Kawamori D, Hu J, Meyer J, Kanji M, Bhushan A, Kulkarni RN. Cyclin D2 is essential for the compensatory $\beta$-cell hyperplastic response to insulin resistance in rodents. Diabetes. 2010;59(4):987–996.
Robertson S, Ishida-Takahashi R, Tawara I, Hu J, Patterson CM, Jones JC, Kulkarni RN, Myers MG. Insufficiency of janus kinase 2–autonomous leptin receptor signals for most physiologic leptin actions. Diabetes. 2010;59(4):782–790.
Cornu M, Modi H, Kawamori D, Kulkarni RN, Joffraud M, Thorens B. Glucagon-like peptide-1 (GLP-1) increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor (IGF-1R) expression. Journal of Biological Chemistry. 2010;285(14):10538–10545.
Liew CW, Bochenski J, Kawamori D, Hu J, Leech CA, Wanic K, Malecki M, Warram JH, Qi L, Krolewski AS, et al. The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta-cells. The Journal of clinical investigation. 2010;120(8):2876–2888.
Cheng K, Ho K, Stokes R, Scott C, Lau SM, Hawthorne WJ, O\textquoterightConnell PJ, Loudovaris T, Kay TW, Kulkarni RN, et al. Hypoxia-inducible factor-1alpha regulates beta-cell function in mice and in human islets. The Journal of clinical investigation. 2010;120(6):2171–2183.
Kawamori D, Welters HJ, Kulkarni RN. Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction. In: The Islets of Langerhans. Springer; 2010. pp. 421–445.
Bouche C, Lopez X, Fleischman A, Cypess AM, O\textquoterightShea S, Stefanovski D, Bergman RN, Rogatsky E, Stein DT, Kahn R, et al. Insulin enhances glucose-stimulated insulin secretion in healthy humans. Proceedings of the National Academy of Sciences. 2010;107(10):4770–4775.
Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, et al. Class IA phosphatidylinositol 3-kinase in pancreatic beta-cells controls insulin secretion by multiple mechanisms. Cell metabolism. 2010;12(6):619–632.
Kulkarni RN. GIP: no longer the neglected incretin twin?. Science translational medicine. 2010;2(49):49ps47–49ps47.