Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim Y-B, et al. Abnormal glucose homeostasis in skeletal muscle–specific PGC-1 alpha knockout mice reveals skeletal muscle–pancreatic beta cell crosstalk. The Journal of clinical investigation. 2007;117(11):3463–3474.
Publications
2007
Morioka T, Asilmaz E, Hu J, Dishinger JF, Kurpad AJ, Elias CF, Li H, Elmquist JK, Kennedy RT, Kulkarni RN. Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. The Journal of clinical investigation. 2007;117(10):2860–2868.
Matsumura K, Chang BH-J, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L. Aquaporin is a beta-cell protein and regulator of intra-islet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Molecular and cellular biology. 2007;27(17):6026–6037.
2006
He Z, Opland DM, Way KJ, Ueki K, Bodyak N, Kang PM, Izumo S, Kulkarni RN, Wang B, Liao R, et al. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arteriosclerosis, thrombosis, and vascular biology. 2006;26(4):787–793.
Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM, Peters JL, Shackman JG, Zhang M, Artner I, et al. Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nature genetics. 2006;38(5):583.
Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, MacLeod IX, Liew CW, Kulkarni RN, Bain J, et al. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. science. 2006;312(5781):1763–1766.
Neubauer N, Kulkarni RN. Molecular approaches to study control of glucose homeostasis. ILAR journal. 2006;47(3):199–211.
Koh H-J, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, et al. Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Molecular and cellular biology. 2006;26(22):8217–8227.
2005
Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. American Journal of Physiology-Endocrinology and Metabolism. 2005;289(2):E337–E346.
Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng Y-H, Roberson RS, Ricordi C, O\textquoterightConnell PJ, Gonzalez FJ, et al. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell. 2005;122(3):337–349.